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M9460646.TXT
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1994-06-25
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Document 0646
DOCN M9460646
TI Immunoglobulin class and subclass antibodies to HIV proteins in maternal
serum: association with perinatal transmission.
DT 9408
AU Mann DL; Hamlin-Green G; Willoughby A; Landesman SH; Goedert JJ;
Immunogenetics Section, NCI-Frederick Cancer Research and; Development
Center, Maryland 21702-1201.
SO J Acquir Immune Defic Syndr. 1994 Jun;7(6):617-22. Unique Identifier :
AIDSLINE MED/94231467
AB A flow cytometry-based assay for detection of immunoglobulin (Ig) class
and subclass antibodies in human serum or plasma was developed. With use
of this procedure, the presence and relative frequency of antibody
activity in the Ig classes and subclasses (IgA1, IgA2, IgD, IgE, IgG1,
IgG2, IgG3, IgG4, and IgM) to human immunodeficiency virus type 1
(HIV-1) proteins (gp160, gp120, p66, and p24) was determined in serum or
plasma from a cohort of 47 HIV-1-infected, pregnant women. Antibody
activity in each of the classes and subclasses was found with
differences in frequency depending on the Ig class/subclass and the
HIV-1 protein. IgG1 antibodies were the most frequently reactive Ig
class/subclass to each protein. Intermediate frequencies of reactivity
were found in IgA1, IgG2, IgG3, and IgM class and subclasses and
antibodies of the IgA2, IgE, and IgG4 class/subclass the least
frequently detected. An unexpected finding was the presence of IgD
antibodies to HIV-1 proteins in approximately 50% of the individuals.
The distributions of Ig class/subclass antibodies to the different HIV-1
proteins were compared in sera from 14 mothers giving birth to infants
who were determined to be HIV-1 infected with sera from 25 individuals
whose infants were not infected. Sera from transmitting mothers
contained a broader distribution of class and subclass antibodies
compared to sera from nontransmitting women. The single most frequent
antibody-antigen combination that was found in the transmitting mother
was IgG2-gp160.(ABSTRACT TRUNCATED AT 250 WORDS)
DE Cohort Studies Female Flow Cytometry Gene Products, env/IMMUNOLOGY
Human HIV Antibodies/*BLOOD HIV Core Protein p24/IMMUNOLOGY HIV
Envelope Protein gp120/IMMUNOLOGY HIV
Infections/*IMMUNOLOGY/TRANSMISSION HIV-1/CHEMISTRY/*IMMUNOLOGY
Immunoglobulins/*BLOOD Infant, Newborn Pregnancy Pregnancy
Complications, Infectious/*IMMUNOLOGY Protein Precursors/IMMUNOLOGY
Reverse Transcriptase/IMMUNOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).